A few colleagues of mine had some problems with IE8 in Windows 7. Whenever they CTRL+clicked on a link in IE8, the new tab would hang. I did not have this problem on my machine (as a developer would say: “it works on my machine”).
Also when the dragged a link from the address bar to their favorites bar, IE8 would crash completely.

After some intensive research one of my colleagues found a solution and posted it on his blog, check it out here.

Some other things that might happen. because of this setup:

• An error will occur when you open the Microsoft SQL Server Management Studio and connect to a SQL Server instance:
  Unable to cast COM object of type ‘System.__ComObject’ to interface type ‘Microsoft.VisualStudio.OLE.Interop.IServiceProvider’. This operation failed because the QueryInterface call on the COM component for the interface with IID ‘{6D5140C1-7436-11CE-8034-00AA006009FA}’ failed due to the following error: No such interface supported (Exception from HRESULT: 0×80004002 (E_NOINTERFACE)). (Microsoft.VisualStudio.OLE.Interop)
• When using Microsoft Exchange’s webmail page, you’re popup’s when creating a new mail message could resolve in a white page (no content)